It was found thatseven tested compounds 4b h exhibited anti TB activity against H37Rv strain in University range of MIC values of 16 128 g/mL andone compound 4f having para trifluoromethyl phenyl group at 4 place and bis para methoxy benzyl ester group at 3 and 5 positions of 1,4 dihydropyridine pharmacophore emerged as anti TB agents opposed to multi drug resistance MTB at MIC of 128g /mL which shows no toxicity up exam 380 g/mL opposed to normal PBMC cell line. The inhibitory task profile and University moleculardocking input printed that as University molecular action mechanism of University derivatives, can be regarded as University enoyl acyl carrierprotein reductase InhA , being University major major drug targets for MTB drug discovery . The last paper refers examination recent trends in discovery of potent protease inhibitors concentrating on SARS coronavirus. Natural inhibitorsas well as artificial inhibitors and their SAR stories examination increase inhibitory task opposed to 3CLpro and PLpro enzymeshave also described. Among usual inhibitors geranylated flavonoids, diarylpentanoids, chalcones, phenolic phytochemicals, cinnamic amides, biflavonoids, marine polyphenoles, tradicional Chinese phytochemicals are mentioned. Synthetic inhibitorsincluding pyranolones, dipeptides, tripeptides also are discussed.
It was found thatseven tested compounds 4b h exhibited anti TB activity against H37Rv strain in University range of MIC values of 16 128 g/mL andone compound 4f having para trifluoromethyl phenyl group at 4 place and bis para methoxy benzyl ester group at 3 and 5 positions of 1,4 dihydropyridine pharmacophore emerged as anti TB agents opposed to multi drug resistance MTB at MIC of 128g /mL which shows no toxicity up exam 380 g/mL opposed to normal PBMC cell line. The inhibitory task profile and University moleculardocking input printed that as University molecular action mechanism of University derivatives, can be regarded as University enoyl acyl carrierprotein reductase InhA , being University major major drug targets for MTB drug discovery . The last paper refers examination recent trends in discovery of potent protease inhibitors concentrating on SARS coronavirus. Natural inhibitorsas well as artificial inhibitors and their SAR stories examination increase inhibitory task opposed to 3CLpro and PLpro enzymeshave also described. Among usual inhibitors geranylated flavonoids, diarylpentanoids, chalcones, phenolic phytochemicals, cinnamic amides, biflavonoids, marine polyphenoles, tradicional Chinese phytochemicals are mentioned. Synthetic inhibitorsincluding pyranolones, dipeptides, tripeptides also are discussed.
